牛蒡子苷元  (-)-Arctigenin

Antitumor agent

Lignan derivative， which shows antitumor， anti-inflammatory， immunomodulatory and neuroprotective activities. Down-regulates anti-apoptotic protein Bcl-X_L. Potent inhibitor of HIV type-I integrase and DNA topoisomerase II. Shows phytoestrogenic and cytotoxic properties against Hep62 cells.    Antagonist for platelet activating factor and Ca²⁺. Blocks the activation of Akt (protein kinase B PKB)  induced by glucose starvation.

PRODUCT PROPERTIES

Alternative Name:

(3R，4R)-4-[(3，4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2-(3H)-furanone

Source/Host:

Isolated from Arctium lappa.

Solubility:

Soluble in DMSO (34mg/ml， heating， sonication) sparingly soluble in water.

Long Term Storage:

-20°C

MW:

372.4

CAS:

7770-78-7

Formula:

C₂₁H₂₄O₆

Purity:

≥97% (HPLC)

Appearance:

White to off-white solid.

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